A Brain Tumor That Results In Obesity
Hypothalamic Obesity (HyOb) is a biological condition caused by a rare brain tumor called craniopharyngioma. The hypothalamus is damaged during surgery to remove the tumor, which has a significant impact on appetite and weight regulation. HyOb is a complex condition arising from miscommunication between the brain and gut.
Hypothalamic obesity is a complicated biological condition that occurs due to a rare brain tumor called craniopharyngioma, which damages the hypothalamus and disrupts appetite and weight regulation.
Is obesity a risk factor for Brain/CNS tumors?
The study found that in females, being overweight or obese is associated with an increased risk of overall brain/CNS tumors, meningiomas, and gliomas. The results were based on a meta-analysis of multiple study arms.
What causes a brain tumor?
The cause of brain tumors is due to DNA changes that stimulate cells to grow and continue living. The exact reason for these DNA changes is unknown for most cases.
What are gliomas and related brain tumors?
Gliomas are brain tumors that originate from cells resembling glial cells which provide support and structure to nerve cells in the brain. These tumors include astrocytoma, glioblastoma, oligodendroglioma and ependymoma. Though some gliomas are benign, most of them are malignant.
What is a Grade 1 brain tumor?
A Grade 1 brain tumor grows slowly and the cells are similar to nearby healthy cells.
Grade 1 tumors are common in children and grow slowly, appearing almost normal under a microscope. They are associated with long-term survival and typically do not require additional therapy after surgery.
What does Grade 3 brain cancer look like?
Grade 3 brain cancer is characterized by rapid tumor growth, high likelihood of spreading into nearby tissues and abnormal tumor cell appearance.
What is the purpose of the brain tumor grading system?
The brain tumor grading system assigns a grade to a tumor based on its highest-grade cells which indicates the tumor's likely growth rate, potential for spreading, and helps in predicting outcomes and treatment planning.
Is brain cancer staged or graded?
Brain cancer is typically graded rather than staged due to its unique behavior, as tumors may migrate within the brain but rarely spread outside of the central nervous system.
Gliomas are tumors that resemble glial cells, which provide support to nerve cells in the brain. They can be classified as astrocytoma, glioblastoma, oligodendroglioma, and ependymoma. While some gliomas are not harmful, the majority are malignant.
In patients with hypothalamus or pituitary gland damage, impaired communication between the gland and the hypothalamus can cause endocrine hormone deficiencies. If left untreated, deficiencies such as growth hormone deficiency or hypothyroidism can contribute to obesity and weight gain.
What is hypothalamic obesity?
Hypothalamic obesity is a complex medical condition that can result from rare brain tumors or other injuries to the hypothalamus. Craniopharyngioma is one such tumor that can cause hypothalamic obesity. Treatment options are available for this condition.
Is there a connection between hypothalamic-hippocampal neurogenesis and obesity?
There is a potential connection between hypothalamic-hippocampal neurogenesis and obesity as nutraceutical and exercise interventions can positively modulate hypothalamic neurogenesis, which can offer a treatment strategy for obesity and weight-loss management. Additionally, the mechanisms related to obesity-induced anxiety and depressive behavior may be facilitated through the hypothalamic-hippocampal connection.
What is the prevalence of hypothalamic obesity in craniopharyngioma?
Hypothalamic obesity occurs in up to 50% of patients with craniopharyngioma, and up to 20% of patients are obese at diagnosis.
Can bariatric surgery treat hypothalamic obesity?
Bariatric surgery may offer potential for the treatment of hypothalamic obesity, but studies have shown limited efficacy and short-lived weight loss. Further research is needed to fully understand its role in managing this condition.
Being overweight or obese is linked to a higher likelihood of developing brain tumors.
How many cases of brain/CNS tumors are there?
The study included a total of 10,219 incident brain/CNS tumor cases, 1,319 meningioma cases, and 2,418 glioma cases.
Which DNA changes increase the risk of brain tumor run?
Some DNA changes that increase the risk of brain tumors run in families, such as those causing neurofibromatosis 1 and 2, tuberous sclerosis, Lynch syndrome, Li-Fraumeni syndrome, Von Hippel-Lindau disease, familial adenomatous polyposis, Cowden syndrome, and Gorlin syndrome.
Who can get a brain tumor?
Brain tumors can affect anyone regardless of age, gender, or race. However, certain types of brain tumors may be more prevalent in specific ethnic groups. Exposure to high levels of radiation also increases the risk of developing a brain tumor.